Ilya Metchnikoff The 1908 Bulgarian ‘yoghurt reform’

Ilya Metchnikoff promoted yoghurt as beneficial to health and longevity. Why was that?

Barbara Orland | 30.10.2018

Ilya Metchnikoff discovered phagocytosis and was one of the first to investigate probiotics. ©CC

In 1908, Ilya Metchnikoff (1845-1916), a Russian zoologist, bacteriologist and immunologist, won the Nobel Prize for discovering the immune response of so-called scavenger cells (phagocytes). Around the same time, he also publicly promoted eating yoghurt as beneficial to health and longevity. Why was that? What prompted this renowned researcher to advocate a change in diet?

Autointoxication

At the time, Metchnikoff was Head of Research at the Pasteur Institute in Paris, where for years he had been intrigued by the notion of how and why humans age. This was a direct extension of his work on immunology, as he believed voracious scavenger cells to be the main culprits in premature ageing. His Études sur la nature humaine (1903) presented his view that ageing is a consequence of “disharmonies in the organisational structure of the human digestive system” (désharmonies dans l’organisation de l’appareil digestif de l’homme). Metchnikoff saw the colon as a harmful organ, a reservoir of undigested food that encourages colonies of putrefactive bacteria. In his opinion, this led to a self-poisoning of sorts (autointoxication) that would challenge the immune system. Since putrefactive bacteria in the intestines produce autotoxins, the older a person became, the greater the risk of scavenger cells in the intestines converting from fighting infection to destroying healthy tissue. Despite this pessimistic view, Metchnikoff considered his work an ‘optimistic philosophy’. He saw bacteriology, in conjunction with digestion and ageing, as a trend-setting science. He believed that, one day, medicine could prolong lives significantly – to up to 150 years, as it was only at this age that humans would reach a natural instinct to die. However, he thought that, at that time, there was no such thing as such a “natural death”; most people died at a younger age due to harmful influences. According to Metchnikoff, it was science’s role to find measures to prolong life for this hypothetical limit to become the norm.

Commemorative stamp showing, from left to right, profiles of Ilya Metchnikoff, Paul Ehrlich (both Nobel Laureates in Medicine in 1908) and Ernest Rutherford (Nobel Laureate in Chemistry in the same year)©Shutterstock/rook76

Ilya Metchnikoff with his microscope©Wellcome Library/CC

Anti-ageing measures

Metchnikoff made various practical proposals for prolonging life, including ‘biological substitute therapies’ through gland transplants or hormone replacement (endocrine rejuvenation). Yet, it was lactic acid bacteria and their role in intestinal flora that fascinated him the most. Louis Pasteur first discovered these bacteria in the 1860s while studying the fermentation of wine. Bacteriologists were then quick to find additional types of lactic acid bacteria. In 1905, the Bulgarian researcher Stamen Grigorov discovered ‘Bacillus bulgaricus’, the lactic acid bacterium responsible for transforming milk into yoghurt. Metchnikoff heard about the young Bulgarian’s research and, two years later – in 1907 – he published his ideas on the health of Bulgaria’s rural populations. He declared that, in his opinion, the local farmers’ long life expectancy was due to their daily consumption of fresh yoghurt.

Fighting bacteria with bacteria

Metchnikoff also gave public presentations, reiterating his view that Bulgarian yoghurt in particular had the capacity to halt the ageing process caused by putrefactive bacteria in the intestines. He called on the public to employ thorough hygiene when handling fresh fruit and vegetables, but pointed out that the matter went beyond simply preventing harmful bacteria from entering the body. According to Metchnikoff, there were also ‘good’ bacteria that could be cultivated by consuming Bulgarian yoghurt and other forms of curdled milk. He alleged that, once in the intestines, these good bacteria would prevent putrefactive bacteria from forming on undigested food. Gripped by a general fear of bacteria, audiences eagerly accepted Metchnikoff’s reports on experiments where he and his team had observed microbes converting lactose into lactic acid, killing off putrefactive bacteria in the process. The Nobel Prize winner preached that the Bacillus bulgaricus found in Bulgarian curdled milk was ideally suited for this task. Since rural populations were consuming large quantities of curdled milk, he added that there was reason to assume that the striking longevity of many Bulgarians could be credited to their intake of yoghurt.

The yoghurt boom

The general public took heed of Metchnikoff’s message that there was a connection between self-poisoning, ageing, and yoghurt as a life-prolonging foodstuff. This led to a rush on yoghurt and other curdled-milk products. While people in Western Europe were familiar with buttermilk or milk that had soured spontaneously, in terms of bacteriology, this was the result of an impure fermentation process (with by-products such as butyric acid, carbonic acid and alcohol). Metchnikoff’s proposal of first boiling the milk to kill off this additional flora and then adding pure cultures of desirable bacterial strains was a completely new approach. The years that followed saw an abundance of specialist medical literature recommend the consumption of yoghurt as a remedy, dietary aid, curative treatment and foodstuff.

Bulgarian yoghurt, an elixir of eternal youth? ©Shutterstock/Nikolina Ivanova

Bulgarian yoghurt became an elixir, and Bacillus bulgaricus the longevity microbe. It was said to cure all possible diseases, including mental illnesses such as depression, melancholia and hypochondria. Pharmacies and chemists across Europe, and subsequently in the United States, started selling ready-made yoghurt, as well as starter cultures in powder and tablet form to be taken just as they were or used to make yoghurt at home. Metchnikoff distanced himself from this profiteering, but it was too late. Nothing could dampen the enthusiasm surrounding the notion of beneficial bacteria fighting harmful bacteria in the body, particularly in the intestines. Yoghurt totally changed dietetics in the 1910s. Undigested proteins from predominantly meat-based diets were considered particularly problematic. The aim of the new diet was to prevent non-absorbed proteins from being broken down in the colon and thus producing toxic metabolic products which, once absorbed in the bloodstream, would lead to a self-poisoning of sorts (autointoxication). The craze for Bulgarian yoghurt finally died down in the 1920s – and even then only because of the discovery of another lactic acid bacterium, Lactobacillus acidophilus, which marked the start of a new wave of promoting bacteriotherapy, the precursor to modern probiotics.

Scientists who changed our diet

Throughout history, many scientists rose to fame for their inventions, discoveries and advice for an improved diet. Here are a few more examples from the 19^th century:

Justus von Liebig (1803-1873) and meat extract

During the famines of the 19^th century, based on the prevalent knowledge of nutrients, many foodstuffs were chemically dissected to obtain new foodstuffs from cheap raw materials. After 1860, this knowledge of chemistry gave rise to a sharp increase in the number of new and industrially treated foodstuffs. The range expanded to include cereals processed into soups, tinned fruit and vegetables, dairy products, sugar, long-life non-alcoholic drinks, chocolate, and products from the oil and fat industry. Justus von Liebig was one of the chemists who played a key role in this process. During the 1850s, he extracted a number of substances from meat broth. This led him to think that this would be largely equivalent to meat extract and could replace meat. After boiling the meat broth down and converting the resultant brown syrup into a dry powder, he decided to launch this product on the market. Initially, this meat extract was produced in pharmacies. Liebig later helped build meat-extract factories in Fray Bentos, Uruguay.

Louis Pasteur (1822-1895) and pasteurisation

While people have known about lactic acid for centuries, it was not until well into the 19^th century that scientists stopped arguing as to whether it was produced chemically, i.e. via fermentation of a decomposing substance, or with the help of microorganisms. Louis Pasteur, a Parisian microbiologist, answered this question in his research on lactic acid fermentation. His famous 1858 study claimed that it required a specific milk enzyme for milk to sour. As part of this study, in 1866 he found a way of combatting “wine and beer illnesses”. He briefly heated food, to less than 100°C, thereby killing off most of the bacteria. This process, known today as pasteurisation, considerably prolongs the shelf life of food without compromising taste or nutritive value.

Max Rubner (1854-1932) and counting calories

Since 1883, it has become common practice to convert the nutrient content of foodstuffs into calories. This was after Max Rubner, a professor in hygiene, proved that individual nutrients were equivalent to one another (the isodynamic law), and was able to present specific calculations in calories for each nutrient. Over the years that followed, Rubner established so-called standard values for most foodstuffs and summarised these in detailed tables. In doing so, he created a practical calorie counter for daily use that remains applicable. Rubner also dedicated a large part of his work to making people aware of ‘efficient nutrition’.

Emil von Behring (1854-1917) and disinfected milk

After the 1880s, more and more bacteria were discovered and preventing infectious diseases became one of the most difficult challenges in medicine. There were still no effective treatments for most known infectious diseases. Since it had been proven that dairy milk contains germs, highly susceptible infants became scientists’ main priority. Emil von Behring, an immunologist and winner of the 1901 Nobel Prize for developing a serum against diphtheria, came up with the following idea: In 1903, he had a herd of cattle vaccinated against tuberculosis. He then tested various methods for stopping the decomposition of milk that occurred en route from cow to child. In addition to pasteurising it both with and without the use of antiputrefactive chemicals, as well as adding gases, treating it electrically, and extracting water, he found that formaldehyde was the only chemical that inhibited decomposition without giving the milk an unpleasant taste. Over the years that followed, this developed into perhydrase milk, yet the idea of disinfecting milk did not become standard practice and was soon forgotten.

Bibliography and Links

METCHNIKOFF, Elie, 1904. La vieillesse. Revue scientifique. 1904. Vol. I, pp. 65-70; vol. II, pp. 100-105.

METCHNIKOFF, Elie, 1908.Quelques remarques sur le lait aigri [online]. Paris: E. Rémy. [Accessed on 21.08.2018]. Available on: https://hal-pasteur.archives-ouvertes.fr/pasteur-00724105v2/document

STOILOVA, Elitsa, 2015. The Bulgarianization of Yoghurt: Connecting Home, Taste, and Authenticity. Food and Foodways. 10.06.2015. Vol. 23, n^o 1-2, pp. 14-35.

VIKHANSKI, Luba, 2016.Immunity: How Elie Metchnikoff Changed the Course of Modern Medicine. Chicago: Chicago Review Press.

WOLFF, A., 1913. Was ist Yoghurt und Intestibakter, und worin besteht deren Wirkung? Pharmazeutische Zentralhalle für Deutschland. Zeitschrift für wissenschaftliche und geschäftliche Interessen der Pharmazie. 1913. Vol. 54, pp. 1178-1181.